active pharmaceutical ingredients
micronization and powdering
contract manufacturingactive pharmaceutical ingredients
micronization and powdering
contract manufacturing
Technical capabilities
Activities:
- organic synthesis – active pharmaceutical ingredients, chemical intermediates including:
- synthesis of chiral active pharmaceutical ingredients
- synthesis with chiral substrates
- synthesis including alkaline cyanides application
- synthesis of 5-membered heterocyclic rings
- development of processes and technologies
- powdering and micronization
Expertise and capability to conduct following transformations:
- Grignard reactions
- reactions utilizing Cl2, Br2, KCN, SOCl2
- catalytic hydrogenation (50 atm)
- diazotization
- chiral compounds
Technical support:
- API processing plant
- Four-floor production plant for operations in temperatures between -30 and 200°C and under pressures between 3 Tr and 50 atm
- Two-floor production plant for post-critical stages in API’s manufacturing
- Light-roof production shelter for operations utilizing dangerous gas reagents
- Excellently equipped analytical and research laboratories
Ipochem plants are equipped with:
| REACTORS | CAPACITY | QUANTITY |
|---|---|---|
| Steel glass-lined | 1300 L | 4 |
| Steel glass-lined | 500-600 L | 9 |
| Steel glass-lined | 250 L | 6 |
| Hastelloy | 1600 L | 1 |
| Hastelloy | 70 L | 1 |
| Glass | 30-100 L | 30 |
| PROCESSING SETS | CHARACTERISTICS | QUANTITY |
|---|---|---|
| Vacuum distillations 50, 150, 250 L | Tmax = 200°C; pmin = 3-30 Tr | 5 |
| Azeotropic distillations 250, 600 L | Tmax = 200°C | 2 |
| patm distillations 250, 500, 1000 L | Tmax = 150°C | 4 |
| Rectifications 100, 250 L | Tmax = 150 - 200°C | 3 |
| Crystallizations 150, 250, 500 L | 3 | |
| Rotary evaporators 10, 20, 50 L | pmin = 3 Tr | 8 |
| PLANT INSTALLATIONS | CHARACTERISTICS |
|---|---|
| Central Vacuum | pmin = 30 Tr |
| Low Vacuum | pmin = 2 - 3 Tr |
| Central Process Steam | pmax = 6 atm |
| Compressed Air | pmax = 6 atm |
| Cooling (ethylene glycol) | -35°C |
| Heating (process steam, oil) | 160°C, 250°C |
| OTHER EQUIPMENT | CHARACTERISTICS |
|---|---|
| Filters (pressure, vacuum, flow) | 20 - 300 L |
| Dryers (tray vacuum, shelves, fluid bed) | Tmax = 130°C |
| Grinders (jet mill, oscillating granulators) |